phenobarbital will decrease the level or impact of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Solid or moderate CYP3A4 inducers could boost level of diazepam elimination; as a result, efficacy of diazepam may be diminished.This system is most likely with the induction of hepatic microsomal e